Neomycin does not interfere with the inositol phospholipid metabolism, but blocks binding of alpha-thrombin to intact human platelets.
نویسندگان
چکیده
Neomycin was demonstrated to inhibit the binding of thrombin to intact human platelets. The effects of neomycin on both thrombin binding and thrombin-induced changes in inositol phospholipid metabolism could be reproduced by the thrombin antagonist hirudin. We propose that neomycin inhibits thrombin-induced platelet activation by interference with the cellular receptor.
منابع مشابه
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عنوان ژورنال:
- The Biochemical journal
دوره 273(Pt 1) شماره
صفحات -
تاریخ انتشار 1991